I got a Nook Color for Christmas several years ago. I LOVE the thing, and I haven't even rooted it yet. With the wifi support, I can jump online just about anywhere. It has Flash support, which gives me a bit more flexibility and control than Apple products do (even though I loathe Flash). It has support for apps, though I don't like that I'm locked into B&N's app store, and don't have access to either the Android Marketplace or the Amazon store (and yes, I know if I root it it solves those issues, but that's beside the point).
But there is one thing about the device I DO NOT like, at all, period, end of story.
There is a software issue around battery life.
How do I know it's a software issue? Because a hard reset to factory defaults resolves the problem.
So, what's the problem with the battery? Well, occasionally the device will stop going into sleep or hibernate modes, even though the screen blanks out. This means battery consumption is going on at full tilt in the background, even though you think you shut it down. 8 hours or so later, you have a dead Nook. Recharge, wash, rinse, repeat. The only way to "fix" the problem is to do a hard reset to factory defaults.
Once you do that, say goodbye to your background, your desktop settings, basically any customizations you've made to your setup. You get to do all that again, and it can be a pain.
I had hoped the last OS patch would fix the problem, but evidently not, since it just happened to me again. At least this time, I've figured out the common cause, and least for every time I've experienced the issue.
DO NOT LET YOUR BATTERY FULLY DISCHARGE!
Every time I've had the problem, it's after I've allowed the battery to run flat. Keep it charged up, and it keeps trucking. If a reset to factory defaults resolves the problem, then there must be a software fix that will resolve the problem.
B&N Engineering and Development and R&D, I'm looking at you guys. I've diagnosed it for you (but I'm going to guess you're already aware of it). Now reproduce the problem (won't take you more than 10 hours or so) and fix it.
I am waiting not-so-patiently.
Edited to add: The @NOOK_Care twitter feed provided me an email address to someone at B&N, and asked me to send them an email. I have done so, and will post any updates or replies that I receive.